Blar i forfatter "Stensen, Wenche Gunvor Berg"

Viser treff 1-3 av 3

    • DYRK1a Inhibitor Mediated Rescue of Drosophila Models of Alzheimer’s Disease-Down Syndrome Phenotypes 

      Zhu, Bangfu; Parsons, Tom; Stensen, Wenche Gunvor Berg; Svendsen, John Sigurd Mjøen; Fugelli, Anders; Hodge, James W.L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-19)
      Alzheimer’s disease (AD) is the most common neurodegenerative disease which is becoming increasingly prevalent due to ageing populations resulting in huge social, economic, and health costs to the community. Despite the pathological processing of genes such as Amyloid Precursor Protein (APP) into Amyloid-β and Microtubule Associated Protein Tau (MAPT) gene, into hyperphosphorylated Tau tangles being ...

    • Lactoferricin-inspired peptide AMC-109 augments the effect of ciprofloxacin against Pseudomonas aeruginosa biofilm in chronic murine wounds 

      Laulund, Anne Sofie; Schwartz, Franziska Angelika; Christophersen, Lars; Høiby, Niels; Svendsen, John Sigurd Mjøen; Stensen, Wenche Gunvor Berg; Thomsen, Kim; Cavanagh, Jorunn Pauline; Moser, Claus (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-23)
      Objectives: Chronic wounds are characterised by prolonged inflammation, low mitogenic activity, high protease/low inhibitor activity, microbiota changes and biofilm formation, combined with the aetiology of the original insult. One strategy to promote healing is to terminate the parasitism-like relationship between the biofilm-growing pathogen and host response. Antimicrobial peptide AMC-109 is a ...

    • Lateral membrane organization as target of an antimicrobial peptidomimetic compound 

      Melcrová, Adéla; Maity, Sourav; Melcr, Josef; de Kok, Niels A. W.; Gabler, Mariella; van der Eyden, Jonne; Stensen, Wenche Gunvor Berg; Svendsen, John Sigurd Mjøen; Driessen, Arnold J. M.; Marrink, Siewert J.; Roos, Wouter H. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-07)
      Antimicrobial resistance is one of the leading concerns in medical care. Here we study the mechanism of action of an antimicrobial cationic tripeptide, AMC-109, by combining high speed-atomic force microscopy, molecular dynamics, fluorescence assays, and lipidomic analysis. We show that AMC-109 activity on negatively charged membranes derived from Staphylococcus aureus consists of two crucial steps. ...